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Sleep Surgery Research

As surgical options for obstructive sleep apnea (OSA) continue to develop and become available, questions remain about their effectiveness. Dr. Raj Dedhia, Director of the Emory Sleep Surgery Center, spends 50% of his time as a medical researcher, studying better ways to predict response to OSA surgery and the effects current therapies may have on patient health.

Watch Dr. Dedhia deliver the lecture "Obstructive Sleep Apnea & The Heart: Past, Present and Future" at Emory Heart & Vascular Grand Rounds.

In addition to the trials listed below, Dr. Dedhia is an investigator on a clinical trial at Children's Healthcare of Atlanta at Egleston for hypoglossal nerve stimulation in adolescents with Down Syndrome.

Active Clinical Trials

Dr. Dedhia's team is currently enrolling subjects in two clinical trials:

1. Neostigmine For Snoring During DISE

The team is seeking a novel treatment for snoring involving local application of a nerve stimulant medication called neostigmine. In this study, neostigmine will be injected into five sites of the soft palate during drug-induced sleep endoscopy, a standard procedure, to evaluate the effect on snoring. If successful, development of a topical (non-injectable) version of this drug will be considered, so that the patient can apply it to him/herself before bedtime.

2. Hypoglossal Nerve Stimulation on Cardiovascular Outcomes

A new, well-tolerated treatment known as tongue stimulation is a device which opens the airway during sleep and can provide treatment for patients unable to use the mask and hose treatment. This study will evaluate the effect of this new treatment on blood pressure and heart-related measures to observe if it lowers patients' risk of heart problems.

Completed Projects

Austin Lam

PubMed Links:

"Practice Patterns of Sleep Otolaryngologists at Training Institutions in the United States."

"Validated Measures of Insomnia, Function, Sleepiness, and Nasal Obstruction in a CPAP Alternatives Clinic Population."

Lead Author: Austin Lam, MD

Tyler Halle

PubMed Link:

"Surgical Treatment of OSA on Cardiovascular Outcomes: A Systematic Review."

Lead Author: Tyler Halle, MD

Jack "Will" Shteamer

PubMed Link:

"Sedative Choice In Drug-Induced Sleep Endoscopy: A Neuropharmacology-Based Review."

Lead Author: Jack "Will" Shteamer, MD

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