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Sleep Surgery Research

As surgical options for obstructive sleep apnea (OSA) continue to develop and become available, questions remain about their effectiveness. Dr. Raj Dedhia, Director of the Emory Sleep Surgery Center, spends 50% of his time as a medical researcher, studying better ways to predict response to OSA surgery and the effects current therapies may have on patient health.

Watch Dr. Dedhia deliver the lecture "Obstructive Sleep Apnea & The Heart: Past, Present and Future" at Emory Heart & Vascular Grand Rounds.

In addition to the trials listed below, Dr. Dedhia is an investigator on a clinical trial at Children's Healthcare of Atlanta at Egleston for hypoglossal nerve stimulation in adolescents with Down Syndrome.

Active Clinical Trials

Dr. Dedhia's team is currently enrolling subjects in two clinical trials:

1. Neostigmine For Snoring During DISE

The team is seeking a novel treatment for snoring involving local application of a nerve stimulant medication called neostigmine. In this study, neostigmine will be injected into five sites of the soft palate during drug-induced sleep endoscopy, a standard procedure, to evaluate the effect on snoring. If successful, development of a topical (non-injectable) version of this drug will be considered, so that the patient can apply it to him/herself before bedtime.

2. Hypoglossal Nerve Stimulation on Cardiovascular Outcomes

A new, well-tolerated treatment known as tongue stimulation is a device which opens the airway during sleep and can provide treatment for patients unable to use the mask and hose treatment. This study will evaluate the effect of this new treatment on blood pressure and heart-related measures to observe if it lowers patients' risk of heart problems.

Active Mentored Projects

Clara Lee

Clara H. Lee, BS
4th Year Medical Student

The Discovery Phase is a unique opportunity for fourth-year Emory medical students to engage in a hypothesis-driven research project with a faculty mentor over a period of five months. Given her interests in otolaryngology, sleep medicine, and clinical research, Clara Lee will be working with Dr. Raj Dedhia in the Division of Sleep Surgery.

The overarching aim of Ms. Lee's research block is to identify the patient factors associated with a greater likelihood of success following surgical treatment of obstructive sleep apnea (OSA). At present, she and Dr. Dedhia are studying whether preoperative polysomnography (CPAP) pressures predict patient response to pharyngeal surgery for OSA, the goal being to provide clinicians with evidence-based guidelines for identifying optimal surgical candidates.

Completed Projects

Allison Ikeda

Lead Author: Allison Ikeda, MD

PubMed Link:

"Hypoglossal Nerve Stimulation Therapy on Peripheral Arterial Tonometry In Obstructive Sleep Apnea: A Pilot Study."

Austin Lam

Lead Author: Austin Lam, MD

PubMed Links:

"Practice Patterns of Sleep Otolaryngologists at Training Institutions in the United States."

"Validated Measures of Insomnia, Function, Sleepiness, and Nasal Obstruction in a CPAP Alternatives Clinic Population."

Tyler Halle

Lead Author: Tyler Halle, MD

PubMed Link:

"Surgical Treatment of OSA on Cardiovascular Outcomes: A Systematic Review."

Jack "Will" Shteamer

Lead Author: Jack "Will" Shteamer, MD

PubMed Link:

"Sedative Choice In Drug-Induced Sleep Endoscopy: A Neuropharmacology-Based Review."

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