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Sleep Surgery Research

As surgical options for obstructive sleep apnea (OSA) continue to develop and become available, questions remain about their effectiveness. Dr. Raj Dedhia, Director of the Emory Sleep Surgery Center, spends 50% of his time as a medical researcher, studying better ways to predict response to OSA surgery and the effects current therapies may have on patient health.

Watch Dr. Dedhia deliver the lecture "Obstructive Sleep Apnea & The Heart: Past, Present and Future" at Emory Heart & Vascular Grand Rounds.

Active Clinical Trials

Dr. Dedhia recently began enrolling subjects in the clinical trial, "Effect of Upper Airway Stimulation on Vascular Function in Obstructive Sleep Apnea." The trial is evaluating the effect of hypoglossal nerve stimulation on different measures of cardiovascular function in patients with OSA. Eligible participants must have recently undergone implantation of a hypoglossal nerve stimulator. Participants will undergo a battery of cardiovascular tests, including blood pressure measurements, vascular studies, and bloodwork. The latter will be done before activation of the device, after successful therapy, and following a brief withdrawal period. The goal is to develop an understanding of the cardiovascular effects of this new therapy.

Dr. Dedhia is also an investigator on a clinical trial for hypoglossal nerve stimulation in adolescents with Down Syndrome.

Other Projects

•  Prevalence of Obstructive Sleep Apnea in Cardiology Population

•  Validated Measures of Insomnia, Function, Sleepiness and Nasal Obstruction in CPAP Alternatives Clinic

•  Surgical Treatment of Obstructive Sleep Apnea on Cardiovascular Outcomes: A Systematic Review

•  Impact of Upper Airway Stimulation on Heart Rate Variability: The STAR Trial

•  Hypoglossal Nerve Stimulation on Peripheral Arterial Tonometry in Obstructive Sleep Apnea

Completed Projects

•  Practice Patterns of Sleep Otolaryngologists at Training Institutions in the United States (PubMed link)

•  Sedative Choice in Drug-Induced Sleep Endoscopy: A Neuropharmacology-Based Review (PubMed link)